Cushing’s syndrome

Increased circulating levels of glucocorticoids results in Cushing’s syndrome. In most situations this is caused by therapeutic administration of steroid hormones. Spontaneous cases are rare.

Spontaneous cases can be divided into two categories,

Increased secretion of glucocorticoids due to the increased circulating levels of ACTH from the pituitary.

Increase in endogenous secretion by adrenal tumor or nodular hyperplasia.

Clinical features

Pigmentation – occurs only in higher ACTH levels.

Adrenal diabetes

Moon face and buffalo hump

Characteristic distribution of fat (Less fat in extremities and more fat in the chest and abdomen)

Hypokalaemia due to mineralocorticoid action of glucocorticoids

Treatment

If untreated, has a very bad prognosis

Death can be caused by hypertension, myocardial infarction and heart failure

The usual drug is metyrapone.it is a 11β-hydroxylase blocker.

How to increase your Google page rank?

As you know, many web surfers don’t even know about the Google page rank. But for the web masters and web sites owners it is an achievement. Number of the people around the world try to increase their sites Google page rank but get frustrated because it is not a process of one or two days. Google takes few months to give or change the sites page rank. So the web site owner has to wait and see. But please do not spend money for various web sites around the world to increase your page rank. They will take your money but nothing will happen. (It happened to me to - but keep in mind all are not alike) Also keep in mind, some methods are appropriate, some are not. Please do not submit your site to link farms. Google frown at this method.

I will give you some tips to increase your page rank,

You need to increase the number of inbound links to your site. Try to make sure these links are from appropriate (The site which provides the link should be relevant to your site – this will help you in the future) sites. Quality of the inbound link is is also important. Inbound links from a site which has a higher page rank will count more than the links from a site which has a lower page rank.

To increase the number of inbound links,

Try to submit your web site to many web directories as much as possible (there are some excellent free web directories in the web. Try to submit to these sites first) (I’ll put up a list of free web directories later.)

Take part in forums and use your site URL as a part of your signature. But please don’t over do this and don’t spam the forums. You have to genuinely participate in an ongoing discussion.

Make unique contents for the site. Don’t copy and paste information from the other sites. This remains as THE KING AS ALWAYS. After following these steps you should be able to increase your google page rank. But Don’t get panic. Stay coooooooooool.

Xerography

Meaning of xerography is “dry writing”. Widely used for coping documents letters etc.

Most important part of the xerography is photo conducting. Photo conducting is in light...

In a photocopied drum or plate is made from very thin photo conductor. That is in the top of the metal substance sheet.

Positive charge is spread over the photo conducting using corona discharge. This is done in dark film is an insulator.

Uniform charge is exposure to the light from the image of the original document. The material becomes conducting like hole and charged disturbed. There for at electrostatic image produced.

Negative charged toner particles are spread. They stick with positive charges. Image of toner is transferred to paper charge by the corona wire.

The paper is heated. Then Polyethylene layer is melted and toner particles stick to the paper.

Excess toner will bush and excess charge on the film is disturbed or removed by the shining light.

DNA extraction

Do you know that it is very easy to extract DNA from cells. I didn't knew that. But today in our biochemistry prctical we tried it and it was sccuessful. First you have to find an animal tissue and crush it in ice water. Then centrifuge the mixture. After that spill out the supernant and wash the precipitate with ice water. Then crush it and add 95% ethanol. Then Add a glass rod. You will get DNA winding aroud the glass rod. Try this and let me know your results.